GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2932538 | 1 | rs2932538 | chr1:113216543 | ST7L | chr1:113066142-113162405:- | -0.37 | -5.58 | 4.6E-8 | Systolic blood pressure;Hypertension;Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs2935183 | 1 | rs2935183 | chr17:45607572 | C17orf57 | chr17:45401142-45518675:+ | -0.27 | -6 | 4.65E-9 | Multiple sclerosis or amyotrophic lateral sclerosis |
| BLCA | cis | rs11976180 | 1 | rs2951308 | chr7:143767149 | ARHGEF35 | chr7:143883677-143892736:- | 0.33 | 5.88 | 8.88E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951353 | chr7:143761116 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.97 | 5.43E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951354 | chr7:143761001 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.3E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951360 | chr7:143757349 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.26E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951363 | chr7:143754724 | ARHGEF35 | chr7:143883677-143892736:- | -0.33 | -5.9 | 7.79E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951364 | chr7:143754483 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.98 | 5.07E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951368 | chr7:143752821 | ARHGEF35 | chr7:143883677-143892736:- | -0.33 | -5.9 | 7.79E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951369 | chr7:143752638 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.98 | 5.07E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951371 | chr7:143750328 | ARHGEF35 | chr7:143883677-143892736:- | -0.31 | -5.32 | 1.77E-7 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2951372 | chr7:143749503 | ARHGEF35 | chr7:143883677-143892736:- | -0.33 | -5.87 | 9.2E-9 | Obesity-related traits |
| BLCA | cis | rs73201462 | 1 | rs2955126 | chr3:127926254 | EEFSEC | chr3:127872313-128127488:+ | 0.36 | 3.91 | 0.00011 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| BLCA | cis | rs2243480 | 1 | rs2961102 | chr7:65424658 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.49 | 9.42E-6 | Diabetic kidney disease |
| BLCA | cis | rs11976180 | 1 | rs2961115 | chr7:143753371 | ARHGEF35 | chr7:143883677-143892736:- | -0.33 | -5.9 | 7.79E-9 | Obesity-related traits |